The University of Perpetual Help Rizal System established the first institutional ethics committee in October 2004 through the initiative and recommendation of Dr. Aretas P. Singson-Alday, Dean JFSM and with recommendation of Dr. Rowena Auxillos, UPHRMC Medical Director. The aim was to ensure that the clinical researches conducted at JONELTA Foundation School of Medicine and the University of Perpetual Help Rizal Medical Center conform to ICH GCP guidelines. In January 2006 the University of Perpetual Help Rizal Corporate Center was established. The Institutional Ethics Committee initially formed in 2004 was restructured to become the University of Perpetual Help System-Institutional Ethics Review Board under the Corporate Office for Research specifically the Corporate Vice President for Research.

Since 2006, the objective of the University of Perpetual Help System-Institutional Ethics Review Board was to ensure the protection of the rights, safety and well-being of human subjects involved in health related research and to provide public assurance of that protection. It believes in and adheres to the basic ethical principles – respect for the person and his/her autonomy, beneficence, non-maleficence and justice. It is adherent to international guidelines such as the Declaration of Helsinki, CIOMS International Guidelines, ICH-GCP and WHO Guidelines and the national laws and guidelines such as the PNHRS Act of 2013, the National Ethical Guidelines for Health Research, Department of Science and Technology (DOST) Administrative Order 001 Series of 2007, which requires ethics review of all health research involving human participants; the Department of Science and Technology (DOST) Administrative Order 001 Series 2008, which requires all Ethics Review Committees (ERB)/Institutional Review Committees (IRB) to register with the Philippine Health Research Ethics Board (PHREB); and, the Commission on Higher Education (CHED) Memorandum Order 34 Series 2007 in support of the DOST memorandum, which requires all academic institutions engaged in human research to establish ethics review boards/committees.

The University of Perpetual Help System-Institutional Ethics Review Board reviews all research protocols involving human participants and continues its monitoring review until the end of the study. The scope of the work of the IERB includes researches done by the University faculty members and hospital staff/trainees as well as outside clients of Perpetual Health System.  UPHS-IERB Standard Operating Procedure (SOP) and Guidelines are available in the Office of the Corporate Research, Biomedical Research Institute, Upper Basement, Tamayo Tower, Perpetual Help Medical Center-Las Pinas with email address: cor_uphs@yahoo.com.ph and Tel. No 8733772 or 8748515 local 631

The University of Perpetual Help System-Institutional Ethics Review Board has been granted Level III Ethics Review Committee Accreditation No. L3-2014-015-01 effective November 25, 2014 until November 25, 2017 and has been re-accredited and granted Level III Research Ethics Committee Accreditation No. L3-2018-015-02 effective June 1, 2018 until May 31, 2022 by the Philippine Health Research Ethics Board (PHREB).

The University of Perpetual Help System-Institutional Ethics Review Board has been granted recognition by the Strategic Initiative for Developing Capacity in Ethical Review – Forum for Ethical Review Committees in Asia and the Western Pacific Region (SIDCER-FERCAP) last November 26, 2014 during the 14^th FERCAP General Assembly, Tagaytay City, Philippines.  SIDCER-FERCAP renewed its recognition to University of Perpetual Help System-Institutional Ethics Review Board on November 22, 2017 during the 17^th FERCAP General Assembly in New Delhi, India.